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e.g., angiotensin-converting enzyme inhibitor(s) [ACEi], or angiotensin receptor blockers [ARB]), currently available treatments include sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA), and nonsteroidal mineralocorticoid receptor antagonists (ns-MRA), such as finerenone [5,6,7,8]

The administered active compound is Shanzhiside methylester, utilized in Wistar rats for allodynia testing at concentrations of 10, 30, 100, and 300 g intrathecally, functioning as a GLP-1 receptor agonist [11]

D., Kalyani, R

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Overall, these findings are complementary to results in a companion article 57 , in which the body-weight-reducing and food-intake-reducing effects of GIPR antagonism are disrupted in mice with global loss of either Gipr or Glp1r but preserved in mice with loss of Gipr in either GABAergic or peripheral neurons